Yes, even a nuke.
If you must have a live weapon on set, such as a pistol, or a shotgun, or a nuclear weapon, have one expert dedicated to babysitting that object. They must never let it out of their sight. Pay attention to what they have to say. If they say the actor is being unsafe, fix the actor — don’t shush the expert.
Keep this especially in mind if you plan to film a scene with a bunch of soldiers up on platforms shooting away at an army of zombies. (innocent whistling…)